Evolution or, in human terms, our natural impulse or drive to thrive and advance, is recognized, in Advayavada Buddhism, as the fourth sign of being or caturtha lakshana (cf. conatus, élan vital). To follow the personalized Noble Eightfold Path is our way of responding to it and when the Path is followed conscientiously, it becomes nothing less than the main karmic (and neuroplastic) factor in one’s life, i.e. in one’s fleeting share in the universal interdependent origination process (madhyamaka-pratityasamutpada) that brings forth wondrous overall existence. (from the Advayavada Study Plan)